Design and Synthesis
Over the last 60 years the increasing knowledge of transition metalchemistry has resulted in an enormous advance of homogeneouscatalysis as an essential tool in both academic and industrialfields. Remarkably, phosphorus(III) donor ligands have played animportant role in several of the acknowledged catalytic reactions.The positive effects of phosphine ligands in transition metalhomogeneous catalysis have contributed largely to the evolution ofthe field into an indispensable tool in organic synthesis and theindustrial production of chemicals.
This book aims to address the design and synthesis of acomprehensive compilation of P(III) ligands for homogeneouscatalysis. It not only focuses on the well-known traditionalligands that have been explored by catalysis researchers, but alsoincludes promising ligand types that have traditionally beenignored mainly because of their challenging synthesis.
Topics covered include ligand effects in homogeneous catalysisand rational catalyst design, P-stereogenic ligands, calixarenes,supramolecular approaches, solid phase synthesis, biologicalapproaches, and solubility and separation.
Ligand families covered in this book include phosphine,diphosphine, phosphite, diphosphite, phosphoramidite, phosphonite,phosphinite, phosphole, phosphinine, phosphinidenene,phosphaalkenes, phosphaalkynes, P-chiral ligands, and cageligands.
Each ligand class is accompanied by detailed and reliablesynthetic procedures. Often the rate limiting step in theapplication of ligands in catalysis is the synthesis of the ligandsthemselves, which can often be very challenging and time consuming.This book will provide helpful advice as to the accessibility ofligands as well as their synthesis, thereby allowing researchers tomake a more informed choice.
Phosphorus(III) Ligands in Homogeneous Catalysis: Design andSynthesis is an essential overview of this important class ofcatalysts for academic and industrial researchers working incatalyst development, organometallic and synthetic chemistry.