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Mucus Hypersecretion in Respiratory Disease - Novartis Foundation Symposium

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Mucus Hypersecretion in Respiratory Disease - Novartis Foundation Symposium

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A number of chronic respiratory diseases including chronicbronchitis, asthma, cystic fibrosis and bronchiectasis arecharacterized by mucus hypersecretion. Following damage to theairway epithelium, a repair process of dedifferentiation,regenerative proliferation and redifferentiation takes place thatis invariably accompanied by mucus hypersecretion as a key elementin the host defence mechanism. In chronic respiratory diseases,however, excessive mucus production leads to a pathological statewith increased risk of infection, hospitalization and morbidity. Anunderstanding of the mechanisms that underlie and maintain thishypersecretory phenotype is therefore crucial for the developmentof rational approaches to therapy. Despite a high and increasing prevalence and cost to healthcareservices and society, mucus hypersecretion in chronic respiratorydisease has received little attention until recently, probablybecause of the difficulties inherent in studying this pathology.Only in the last few years have some of the genes involved in mucussecretion been characterized. The recent availability of genomicsequence information and specific antibodies has led to anexplosion of interest in this area making this publicationparticularly timely. This book draws together contributions from an international andinterdisciplinary group of experts, whose work is focused on bothbasic and clinical aspects of the problem. Coverage includesepidemiology, airways infection and mucus hypersecretion, thegenetics and regulation of mucus production, models of mucushypersecretion, and the implications of new knowledge for thedevelopment of novel therapies.
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€ 152,99
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